Phenotypes Associated with This Genotype

Genotype
MGI:3851020

• Allelic Composition: Del(9Cd3g-Cd3d)1Cpt/Del(9Cd3g-Cd3d)1Cpt
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

thymus hypoplasia ( J:76991 )

• thymus cellularity is 2-5% of normal

arrested T cell differentiation ( J:76991 )

• T cell development is blocked at the double negative CD44^-CD25⁺ stage

decreased alpha-beta T cell number ( J:76991 )

• alphabeta T cells are absent in these mice

absent gamma-delta T cells ( J:76991 )

• gammadelta T cells are absent in the thymus, gut, and periphery

immune system

thymus hypoplasia ( J:76991 )

• thymus cellularity is 2-5% of normal

arrested T cell differentiation ( J:76991 )

• T cell development is blocked at the double negative CD44^-CD25⁺ stage

decreased alpha-beta T cell number ( J:76991 )

• alphabeta T cells are absent in these mice

absent gamma-delta T cells ( J:76991 )

• gammadelta T cells are absent in the thymus, gut, and periphery

endocrine/exocrine glands

thymus hypoplasia ( J:76991 )

• thymus cellularity is 2-5% of normal