Phenotypes Associated with This Genotype

Genotype
MGI:3851002

• Allelic Composition: Nodal^tm1Rob/Nodal^tm2Rob
• Genetic Background: involves: 129S/SvEv * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal gastrulation ( J:77125 )

• in some mice

abnormal gastrulation movements ( J:77125 )

• severely affected mice exhibit a decrease in midline tissue compared with wild-type mice due to abnormal gastrulation movements

abnormal rostral-caudal axis patterning ( J:77125 )

• at E8.5, mice exhibit a reduction in anterior neural tissues compared with wild-type mice

absent notochord ( J:77125 )

• in some mice

abnormal primitive node morphology ( J:77125 )

• in some mice

fused somites ( J:77125 )

• fused somites

embryonic-extraembryonic boundary constriction ( J:77125 )

• constriction at the boundary in 40% of mice at E6.5

abnormal visceral endoderm morphology ( J:77125 )

• at E6.5, 40% of embryos are abnormal with thickened patch of visceral endoderm characteristic of the anterior visceral endoderm

cardiovascular system

abnormal heart looping ( J:77125 )

• in some mice