Phenotypes Associated with This Genotype

Genotype
MGI:3850845

• Allelic Composition: Nthl1^tm1Yas/Nthl1^tm1Yas
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal DNA repair ( J:77767 )

• crude nuclear extracts endoIII-like glycosylase activity is absent or reduced comapred with wild-type extracts

• nicking activity in crude nulear extracts for thymine glycols and urea is 17% and 27%, respectively, compared with wild-type extracts

• repair of gamma radiation-induced thymine glycols is slower than in wild-type cells

homeostasis/metabolism

abnormal DNA repair ( J:77767 )

• crude nuclear extracts endoIII-like glycosylase activity is absent or reduced comapred with wild-type extracts

• nicking activity in crude nulear extracts for thymine glycols and urea is 17% and 27%, respectively, compared with wild-type extracts

• repair of gamma radiation-induced thymine glycols is slower than in wild-type cells