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Phenotypes Associated with This Genotype
Genotype
MGI:3850730
Allelic
Composition
Lfngtm1Rjo/Lfngtm1Rjo
Genetic
Background
B6.129S7-Lfngtm1Rjo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lfngtm1Rjo mutation (0 available); any Lfng mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• anterograde shifts of the cranial and caudal borders of the multifidus muscles in 13 of 15 mice
• in 6 of 15 mice there is a unilateral or bilateral anterograde shift of the cranial multifidus border to C2 or C1 rather than T2
• results in the addition of new muscle segments with novel insertion sites craniad to T2
• posterograde shifts of the cranial multifidus border are also seen with cranial insertion points at only T6 or T9 rather than T2

skeleton
• fusions and bifurcations resulting in highly variable intercostal distances
• widespread vertebral defects at almost all vertebral levels
• defects are more severe in the lumbar region than in the thoracic and cervical regions
• fusions are seen
• however, the spinous process at T2 is present and distinct


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory