Phenotypes Associated with This Genotype

Genotype
MGI:3850721

• Allelic Composition: Atm^tm1Awb/Atm^tm1Awb; Rad52^tm1Aps/Rad52^tm1Aps
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by gamma-irradiation ( J:90941 )

premature death ( J:90941 )

• median survival is 33 weeks compared to 16 weeks for Atm^tm1Awb homozygotes

neoplasm

increased T cell derived lymphoma incidence ( J:90941 )

• mice develop thymic tumors

decreased lymphoma incidence ( J:90941 )

• unlike in Atm^tm1Awb homozygotes, mice rarely develop T cell lymphomas

immune system

increased T cell derived lymphoma incidence ( J:90941 )

• mice develop thymic tumors

decreased CD4-positive, alpha-beta T cell number ( J:90941 )

• in thymus

decreased CD8-positive, alpha-beta T cell number ( J:90941 )

• in thymus

growth/size/body

decreased body weight ( J:90941 )

• 25%

hematopoietic system

increased T cell derived lymphoma incidence ( J:90941 )

• mice develop thymic tumors

decreased CD4-positive, alpha-beta T cell number ( J:90941 )

• in thymus

decreased CD8-positive, alpha-beta T cell number ( J:90941 )

• in thymus

homeostasis/metabolism

increased mortality induced by gamma-irradiation ( J:90941 )

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:90941 )

• mice develop thymic tumors