Phenotypes Associated with This Genotype

Genotype
MGI:3850671

• Allelic Composition: Igh^tm1(Myc)Janz/Igh⁺; Mdm4^tm1.1Wahl/Mdm4^tm1.1Wahl
• Genetic Background: involves: 129S/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:150341 )

• mice exhibit increased premature lethality compared with Igh^tm1Janz heterozygotes

immune system

increased splenocyte proliferation ( J:150341 )

enlarged spleen ( J:150341 )

enlarged lymph nodes ( J:150341 )

neoplasm

increased lymphoma incidence ( J:150341 )

• lymphomagenesis is accelerated compared to in Igh^tm1Janz heterozygotes

increased B cell derived lymphoma incidence ( J:150341 )

hematopoietic system

increased splenocyte proliferation ( J:150341 )

enlarged spleen ( J:150341 )

liver/biliary system

enlarged liver ( J:150341 )

cellular

increased splenocyte proliferation ( J:150341 )

growth/size/body

enlarged liver ( J:150341 )

enlarged spleen ( J:150341 )