Phenotypes Associated with This Genotype

Genotype
MGI:3850631

• Allelic Composition: Man2a1^tm1Jxm/Man2a1^tm1Jxm; Rag1^tm1Mom/Rag1^tm1Mom
• Genetic Background: B6.129-Rag1^tm1Mom Man2a1^tm1Jxm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

weight loss ( J:124348 )

• severe weight loss

renal/urinary system

increased mesangial cell apoptosis ( J:124348 )

• increased mesangial cell apoptosis between 6 and 9 months of age

increased urine protein level ( J:124348 )

• increased proteinuria

kidney inflammation ( J:124348 )

• exacerbated kidney disease

• increased macrophage infiltration of the kidney

abnormal nephron morphology ( J:124348 )

• nephron loss

• increased tissue sclerosis

immune system

kidney inflammation ( J:124348 )

• exacerbated kidney disease

• increased macrophage infiltration of the kidney

homeostasis/metabolism

increased urine protein level ( J:124348 )

• increased proteinuria

integument

alopecia ( J:124348 )

cellular

increased mesangial cell apoptosis ( J:124348 )

• increased mesangial cell apoptosis between 6 and 9 months of age