Phenotypes for Man2a1 Rag1 MGI:3850631 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Man2a1^tm1Jxm/Man2a1^tm1Jxm Rag1^tm1Mom/Rag1^tm1Mom
Genetic Background	B6.129-Rag1^tm1Mom Man2a1^tm1Jxm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Man2a1^tm1Jxm mutation (1 available); any Man2a1 mutation (64 available)
Rag1^tm1Mom mutation (56 available); any Rag1 mutation (132 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

weight loss ( J:124348 )

• severe weight loss

renal/urinary system

increased mesangial cell apoptosis ( J:124348 )

• increased mesangial cell apoptosis between 6 and 9 months of age

increased urine protein level ( J:124348 )

• increased proteinuria

kidney inflammation ( J:124348 )

• exacerbated kidney disease

• increased macrophage infiltration of the kidney

abnormal nephron morphology ( J:124348 )

• nephron loss

• increased tissue sclerosis

immune system

kidney inflammation ( J:124348 )

• exacerbated kidney disease

• increased macrophage infiltration of the kidney

homeostasis/metabolism

increased urine protein level ( J:124348 )

• increased proteinuria

integument

alopecia ( J:124348 )

cellular

increased mesangial cell apoptosis ( J:124348 )

• increased mesangial cell apoptosis between 6 and 9 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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