Phenotypes Associated with This Genotype

Genotype
MGI:3850561

• Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal thymus epithelium morphology ( J:125864 )

• medullary thymic epithelial cells that present self antigen are present in these mice

abnormal double-negative T cell morphology ( J:112990 )

• the number of CD44^-HSA⁺CD25^- DN thymyoctes is 2% of controls

• less proportion of these cells are actively cycling compared to controls

decreased inflammatory response ( J:94420 )

• intracolonic administration of the F2r (PAR-1) activating peptide, TFLLR, fails to induce inflammation in mutant colons as in wild-type mice

nervous system

abnormal neuron proliferation ( J:170591 )

• decrease in hippocampal neurogenesis

hematopoietic system

abnormal thymus epithelium morphology ( J:125864 )

• medullary thymic epithelial cells that present self antigen are present in these mice

abnormal double-negative T cell morphology ( J:112990 )

• the number of CD44^-HSA⁺CD25^- DN thymyoctes is 2% of controls

• less proportion of these cells are actively cycling compared to controls

cellular

abnormal neuron proliferation ( J:170591 )

• decrease in hippocampal neurogenesis

endocrine/exocrine glands

abnormal thymus epithelium morphology ( J:125864 )

• medullary thymic epithelial cells that present self antigen are present in these mice