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Phenotypes Associated with This Genotype
Genotype
MGI:3850532
Allelic
Composition		 Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0
Tg(GFAP-CRYAB)141.6Mes/0
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation (2 available); any Gfap mutation (46 available)
Tg(GFAP)10Mes mutation (0 available)
Tg(GFAP-CRYAB)141.6Mes mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:146191 )
N
• all animals survive compared to Tg(GFAP-Cryab)141.6Mes-positive double mutants which die around 30 days of age

nervous system
abnormal hippocampus morphology ( J:146191 )
• Rosenthal fibers are observed, but numbers are significantly less than in Gfaptm2Hgmn/+/Tg(GFAP)10Mes animals; both soluble and insoluble GFAP levels are reduced

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory