Phenotypes Associated with This Genotype

Genotype
MGI:3850529

• Allelic Composition: Del(9Hspb2-Cryab)1Wawr/Del(9Hspb2-Cryab)1Wawr; Tg(GFAP)10Mes/0; Tg(GFAP-CRYAB)141.6Mes/0
• Genetic Background: involves: 129S4/SvJae * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:146191 )

• majority of animals (about 90%) survive to 3 months of age

growth/size/body

growth/size/body region phenotype ( J:146191 )

N • mice show significantly increased body weights at 6 weeks and three months relative to Tg(GFAP)10Mes and Tg(GFAP)10/Tg(GFAP-Cryab)141.6Mes Cryab-null animals; weights are comparable to wild-type

nervous system

abnormal hippocampus morphology ( J:146191 )

• Rosenthal fibers which outline astrocytic processes are present in mutants