Analysis Tools
mortality/aging
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• one third of mice null for Cryab show survival to 100 days compared to Cryab-sufficient Tg(GFAP)10Mes mice which display <10% mortality at about 30 days of age; most animals die at about 30 days of age
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growth/size/body
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• mice show significantly decreased body weights at 6 weeks and three months relative to wild-type
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nervous system
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• by 3 months of age, animals show formation of ubiquinated astrocytic protein (Rosenthal fiber) aggregates in the hippocampus (dentate gyrus and near pial surface of superior colliculus)
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