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Phenotypes Associated with This Genotype
Genotype
MGI:3850449
Allelic
Composition
Cdkn2atm1.1Brn/Cdkn2a+
Nf2tm2Gth/Nf2tm2Gth
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1.1Brn mutation (2 available); any Cdkn2a mutation (26 available)
Nf2tm2Gth mutation (3 available); any Nf2 mutation (47 available)
Trp53tm1Brn mutation (6 available); any Trp53 mutation (142 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• following adenoviral cre treatment, the parietal pleura often shows invasion with concomitant pleural effusion (J:132943)
• following adenoviral cre treatment, the parietal pleura often shows invasion with concomitant pleural effusion (J:132943)
• following adenoviral cre treatment, 94% of mice develop aggressive thoracic tumors (including malignant mesotheliomas, 15 of 51; and rhabdomyosarcomas, 1 of 51) with the parietal pleura often showing invasion with concomitant pleural effusion (J:132943)
• following adenoviral cre treatment, 1% of mice develop aspecific tumors not induced by adeno-cre treatment (J:132943)
• following adenoviral cre treatment, 94% of mice develop aggressive thoracic tumors (including malignant mesotheliomas, 15 of 51; and rhabdomyosarcomas, 1 of 51) with the parietal pleura often showing invasion with concomitant pleural effusion (J:132943)
• following adenoviral cre treatment, 1% of mice develop aspecific tumors not induced by adeno-cre treatment (J:132943)

homeostasis/metabolism
• following adenoviral cre treatment, the parietal pleura often shows invasion with concomitant pleural effusion (J:132943)
• following adenoviral cre treatment, the parietal pleura often shows invasion with concomitant pleural effusion (J:132943)

respiratory system
• following adenoviral cre treatment, the parietal pleura often shows invasion with concomitant pleural effusion (J:132943)
• following adenoviral cre treatment, the parietal pleura often shows invasion with concomitant pleural effusion (J:132943)

Mouse Models of Human Disease
OMIM ID Ref(s)
Mesothelioma, Malignant; MESOM 156240 J:132943


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory