Mouse Genome Informatics
cn
    Cdkn2atm1.1Brn/Cdkn2a+
Nf2tm2Gth/Nf2tm2Gth
Trp53tm1Brn/Trp53tm1Brn

involves: 129P2/OlaHsd * 129S7/SvEvBrd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• following adenoviral cre treatment, the parietal pleura often shows invasion with concomitant pleural effusion
• following adenoviral cre treatment, 94% of mice develop aggressive thoracic tumors (including malignant mesotheliomas, 15 of 51; and rhabdomyosarcomas, 1 of 51) with the parietal pleura often showing invasion with concomitant pleural effusion
• following adenoviral cre treatment, 1% of mice develop aspecific tumors not induced by adeno-cre treatment

homeostasis/metabolism
• following adenoviral cre treatment, the parietal pleura often shows invasion with concomitant pleural effusion

respiratory system
• following adenoviral cre treatment, the parietal pleura often shows invasion with concomitant pleural effusion

Mouse Models of Human Disease
OMIM IDRef(s)
Mesothelioma, Malignant; MESOM 156240 J:132943