Phenotypes Associated with This Genotype

Genotype
MGI:3850410

• Allelic Composition: Nf2^tm2Gth/Nf2⁺; Trp53^tm1Brd/Trp53⁺; Tg(Mpz-cre)3Brn/0
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:92413 )

• mice exhibit a decrease in survival rate when the Nf2 and Trp53 alleles are carried in cis as opposed to trans, but live longer than conditional mutants carrying Tg(P0-Cre)2Gth

neoplasm

increased neurofibrosarcoma incidence ( J:92413 )

• between 3.5 and 13.5 months,19% of mice develop malignant peripheral nerve sheath tumors when the Nf2 and Trp53 alleles are carried in cis

• however, no tumors form in mice when the Nf2 and Trp53 alleles are carried in trans

increased skeletal tumor incidence ( J:92413 )

• when the Nf2 and Trp53 alleles are carried in trans mice develop osteogenic tumors not restricted to neural crest-derived bone

increased osteosarcoma incidence ( J:92413 )

• 81% of mice develop osteogenic (osteomas and osteosarcomas) tumors when the Nf2 and Trp53 alleles are carried in cis

increased osteoma incidence ( J:92413 )

• 81% of mice develop osteogenic (osteomas and osteosarcomas) tumors when the Nf2 and Trp53 alleles are carried in cis

skeleton

increased skeletal tumor incidence ( J:92413 )

• when the Nf2 and Trp53 alleles are carried in trans mice develop osteogenic tumors not restricted to neural crest-derived bone

increased osteosarcoma incidence ( J:92413 )

• 81% of mice develop osteogenic (osteomas and osteosarcomas) tumors when the Nf2 and Trp53 alleles are carried in cis

increased osteoma incidence ( J:92413 )

• 81% of mice develop osteogenic (osteomas and osteosarcomas) tumors when the Nf2 and Trp53 alleles are carried in cis

nervous system

increased neurofibrosarcoma incidence ( J:92413 )

• between 3.5 and 13.5 months,19% of mice develop malignant peripheral nerve sheath tumors when the Nf2 and Trp53 alleles are carried in cis

• however, no tumors form in mice when the Nf2 and Trp53 alleles are carried in trans