Phenotypes Associated with This Genotype

Genotype
MGI:3850408

• Allelic Composition: Nf2^tm2Gth/Nf2^tm2Gth; Trp53^tm1Brd/Trp53^tm1Brd; Tg(Mpz-cre)2Brn/0
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:92413 )

• mice die a few months of birth

neoplasm

osseous metaplasia ( J:92413 )

• 38% of mice develop osseous metaplasia

increased tumor incidence ( J:92413 )

increased sarcoma incidence ( J:92413 )

• at 2 to 3.5 months, 25% of mice develop 4 sarcoma mainly in the ganglia

increased rhabdomyosarcoma incidence ( J:92413 )

• in one mouse

increased neurofibrosarcoma incidence ( J:92413 )

• at 2 to 3.5 months, 50% of mice develop 4 malignant peripheral nerve sheath tumors

increased extremity angiosarcoma incidence ( J:92413 )

• in 63% of mice

increased osteosarcoma incidence ( J:92413 )

• in one mouse

increased osteoma incidence ( J:92413 )

• one mouse developed osteomas

skeleton

increased osteosarcoma incidence ( J:92413 )

• in one mouse

increased osteoma incidence ( J:92413 )

• one mouse developed osteomas

abnormal osteoblast morphology ( J:92413 )

• 25% of mice develop osteogenic hyperplasia

nervous system

abnormal Schwann cell morphology ( J:92413 )

• 38% of mice exhibit Schwann cell hyperplasia

increased neurofibrosarcoma incidence ( J:92413 )

• at 2 to 3.5 months, 50% of mice develop 4 malignant peripheral nerve sheath tumors

renal/urinary system

abnormal renal tubule morphology ( J:92413 )

• 63% of mice exhibit renal tubular cell hyperplasia

vision/eye

cataract ( J:92413 )

• 75% of mice

muscle

increased rhabdomyosarcoma incidence ( J:92413 )

• in one mouse

cellular

abnormal Schwann cell morphology ( J:92413 )

• 38% of mice exhibit Schwann cell hyperplasia