Phenotypes Associated with This Genotype

Genotype
MGI:3850403

• Allelic Composition: Nf2^tm1Gth/Nf2^tm2Gth; Tg(Mpz-cre)#Brn/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:63264 )

• mice exhibit reduced viability

neoplasm

osseous metaplasia ( J:63264 )

• mice exhibit osseous metaplasia in the lung, brain, kidney, and nasal mucosa

increased neurofibrosarcoma incidence ( J:63264 )

increased mesothelioma incidence ( J:63264 )

• one mouse developed a mesothelioma

increased odontoma incidence ( J:63264 )

• 9% of mice develop odontomas and odontosarcomas

increased odontosarcoma incidence ( J:63264 )

• 9% of mice develop odontomas and odontosarcomas

increased Schwannoma incidence ( J:63264 )

• mice develop Schwann cell tumors

skeleton

abnormal tooth development ( J:63264 )

• mice exhibit odontoblastic hyperplasia

abnormal osteoblast morphology ( J:63264 )

• osteoblastic hyperplasia

nervous system

abnormal Schwann cell morphology ( J:63264 )

• 59% of mice exhibit Schwann cell hyperplasia

increased neurofibrosarcoma incidence ( J:63264 )

increased Schwannoma incidence ( J:63264 )

• mice develop Schwann cell tumors

renal/urinary system

abnormal renal tubule morphology ( J:63264 )

• mice exhibit renal tubular cell hyperplasia

craniofacial

abnormal tooth development ( J:63264 )

• mice exhibit odontoblastic hyperplasia

growth/size/body

abnormal tooth development ( J:63264 )

• mice exhibit odontoblastic hyperplasia

cellular

abnormal Schwann cell morphology ( J:63264 )

• 59% of mice exhibit Schwann cell hyperplasia