Phenotypes for Nf2 Tg(Mpz-cre)2Brn MGI:3850394 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Nf2^tm1Gth/Nf2^tm2Gth Tg(Mpz-cre)2Brn/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2^tm1Gth mutation (1 available); any Nf2 mutation (65 available)
Nf2^tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Tg(Mpz-cre)2Brn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:63264 )

premature death ( J:63264 )

• 50% of mice die within the first year

craniofacial

delayed tooth eruption ( J:63264 )

• retarded or absent

failure of tooth eruption ( J:63264 )

• retarded or absent

growth/size/body

delayed tooth eruption ( J:63264 )

• retarded or absent

failure of tooth eruption ( J:63264 )

• retarded or absent

decreased body size ( J:63264 )

decreased body weight ( J:63264 )

hearing/vestibular/ear

increased susceptibility to otitis media ( J:63264 )

immune system

increased susceptibility to otitis media ( J:63264 )

skeleton

delayed tooth eruption ( J:63264 )

• retarded or absent

failure of tooth eruption ( J:63264 )

• retarded or absent

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
otitis media		DOID:10754		J:63264

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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