Phenotypes for Nf2 Tg(Mpz-cre)1Brn MGI:3850393 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Nf2^tm1Gth/Nf2^tm2Gth Tg(Mpz-cre)1Brn/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2^tm1Gth mutation (1 available); any Nf2 mutation (65 available)
Nf2^tm2Gth mutation (3 available); any Nf2 mutation (65 available)
Tg(Mpz-cre)1Brn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:63264 )

• the few mice that are produced die prior to weaning

nervous system

abnormal Schwann cell morphology ( J:63264 )

• at P17, one mouse exhibited a subcutaneous Schwann cell nodule

neoplasm

increased hamartoma incidence ( J:63264 )

• at P19, one mouse exhibited a hamartoma of the olfactory bulb composed of Schwann and neural cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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