Phenotypes Associated with This Genotype

Genotype
MGI:3850390

• Allelic Composition: Nf2^tm2Gth/Nf2^tm2Gth; Tg(Mpz-cre)3Brn/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased fibroadenoma incidence ( J:63264 )

• 12% of mice exhibit fibroadenoma in the mammary gland

osseous metaplasia ( J:63264 )

• 30% of mice develop osseous metaplasia

increased lung adenocarcinoma incidence ( J:63264 )

• in 12% in mice

increased renal carcinoma incidence ( J:63264 )

• 18% of mice develop carcinoma in situ in the kidney

increased sarcoma incidence ( J:63264 )

• 30% of mice develop stromal sarcoma

increased neurofibrosarcoma incidence ( J:63264 )

• 6% of mice develop neurofibrosarcoma

increased osteosarcoma incidence ( J:63264 )

• in 6% of mice

increased odontoma incidence ( J:63264 )

• 6% of mice exhibit odontoma

increased Schwannoma incidence ( J:63264 , J:92413 )

• 30% of mice develop osseous metaplasia (J:63264)

• 6% of mice exhibit odontoma (J:63264)

• 35% of mice develop schwannomas (J:92413)

increased osteoma incidence ( J:63264 )

• 6% of mice develop osteoma

skeleton

abnormal tooth development ( J:63264 )

• 12% of mice exhibit odontoblastic hyperplasia

increased osteosarcoma incidence ( J:63264 )

• in 6% of mice

increased osteoma incidence ( J:63264 )

• 6% of mice develop osteoma

abnormal osteoblast morphology ( J:63264 )

• osteogenic hyperplasia in 47% of mice

nervous system

abnormal Schwann cell morphology ( J:63264 )

• 82% of mice exhibit Schwann cell hyperplasia

increased neurofibrosarcoma incidence ( J:63264 )

• 6% of mice develop neurofibrosarcoma

increased Schwannoma incidence ( J:63264 , J:92413 )

• 30% of mice develop osseous metaplasia (J:63264)

• 6% of mice exhibit odontoma (J:63264)

• 35% of mice develop schwannomas (J:92413)

renal/urinary system

increased renal carcinoma incidence ( J:63264 )

• 18% of mice develop carcinoma in situ in the kidney

abnormal renal tubule morphology ( J:63264 )

• 53% of mice exhibit renal tubular cell hyperplasia

vision/eye

cataract ( J:63264 )

• in 14% to 18% of mice, in which 50% of cases are bilateral

craniofacial

abnormal tooth development ( J:63264 )

• 12% of mice exhibit odontoblastic hyperplasia

growth/size/body

abnormal tooth development ( J:63264 )

• 12% of mice exhibit odontoblastic hyperplasia

respiratory system

increased lung adenocarcinoma incidence ( J:63264 )

• in 12% in mice

integument

increased fibroadenoma incidence ( J:63264 )

• 12% of mice exhibit fibroadenoma in the mammary gland

endocrine/exocrine glands

increased fibroadenoma incidence ( J:63264 )

• 12% of mice exhibit fibroadenoma in the mammary gland

cellular

abnormal Schwann cell morphology ( J:63264 )

• 82% of mice exhibit Schwann cell hyperplasia