Phenotypes Associated with This Genotype

Genotype
MGI:3850373

• Allelic Composition: Krt19^tm2Mmt/Krt19^tm2Mmt; Krt8^tm1Rgo/Krt8^tm1Rgo
• Genetic Background: FVB.129S2-Krt19^tm2Mmt Krt8^tm1Rgo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:65498 )

• after E9.5, the number of double homozygotes declines gradually, with increasing numbers of necrotic remnants and resorption sites

• although some double homozygotes are still alive at E9.75-E10.5, they exhibit small placentas and varying degrees of growth retardation

embryo

embryonic growth retardation ( J:65498 )

• at E9.75-E10.5, live double homozygotes display varying degrees of growth retardation

abnormal allantois morphology ( J:65498 )

• at E10.5, the allantois is poorly formed and shows signs of degeneration

abnormal placenta morphology ( J:65498 )

• as early as E9.5, double homozygotes display placental defects that cause flooding of the maternal blood into the embryonic placenta

abnormal placenta labyrinth morphology ( J:65498 )

• at E9.5, labyrinthine trophoblast cells are decreased in number and appear to be poorly organized

• at E10.5, degeneration of the labyrinthine trophoblasts is observed

abnormal placental labyrinth vasculature morphology ( J:65498 )

• by E10.5, placental vascular structures are deteriorated while maternal and embryonic blood cells display signs of degeneration

small placenta ( J:65498 )

• at E9.75-E10.5, placentas are smaller than normal

abnormal trophoblast layer morphology ( J:65498 )

• at E10.5, trophoblastic tissues contain lesions filled with unnucleated maternal erythrocytes as well as some large and nucleated embryonic erythrocytes

abnormal trophoblast giant cell morphology ( J:65498 )

• at E9.5, giant trophoblasts are pulled apart and display significantly larger cell bodies and nuclei

increased trophoblast giant cell number ( J:65498 )

• a significant increase in the number of secondary giant cells is noted at E9.5

• at E10.5, multiple layers of giant cells are observed

abnormal spongiotrophoblast layer morphology ( J:65498 )

• at E10.5, degeneration of the spongiotrophoblasts is observed

abnormal spongiotrophoblast cell morphology ( J:65498 )

• at E9.5, spongiotrophoblast cells appear to be poorly organized

decreased spongiotrophoblast cell number ( J:65498 )

• at E9.5, spongiotrophoblast cells are decreased in number

impaired placental function ( J:65498 )

• at E9.5, double homozygotes display flooding of maternal blood into the embryonic placenta in the absence of overt clotting

growth/size/body

embryonic growth retardation ( J:65498 )

• at E9.75-E10.5, live double homozygotes display varying degrees of growth retardation

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:65498 )

• by E10.5, placental vascular structures are deteriorated while maternal and embryonic blood cells display signs of degeneration