Phenotypes Associated with This Genotype

Genotype
MGI:3850372

• Allelic Composition: Krt19^tm2Mmt/Krt19^tm2Mmt
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:65498 )

• Background Sensitivity: fewer homozygotes than expected are recovered after one or two backcrosses to FBV/N whereas normal numbers of homozygotes are obtained from heterozygous crosses between parents in the C57BL/6 and 129/Sv backgrounds (F1) or after one or two backcrosses to C57BL/6

• however, surviving homozygotes are viable, fertile, and phenotypically indistinguishable from heterozygous and wild-type littermates in terms of gross anatomy, histology, and behavior up to 20 months of age