Phenotypes Associated with This Genotype

Genotype
MGI:3850351

• Allelic Composition: Sox18^Ra-Op/Sox18^Ra-Op
• Genetic Background: B6D2-Sox18^Ra-Op/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:143564 , J:150211 )

• mice die before E14.5 (J:143564)

• mice do not survive beyond E14.5 (J:150211)

cardiovascular system

cardiovascular system phenotype ( J:150211 )

N • between E8.5 and E10.5, differentiation, proliferation, migration and association of endothelial cells, and patterning and establishment of the primary vascular plexus is normal

abnormal blood vessel morphology ( J:150211 )

• at E12.5, 67% of mice exhibit enlarged surface microvasculature in the trunk, head, proximal limb and neck unlike in wild-type mice

• subdermal microvasculature diameter is increased 21% at E12.5 and 35% at E13.5 compared to in wild-type mice

• vascular defects increase in severity with age

• at E13.5, all mice exhibit enlarged surface microvasculature compared to in wild-type mice

• at E14.5, surface microvessels, particularly around the anterior cranial region, are enlarged compared to in wild-type mice

• enlarged blood vessels frequently rupture

increased vascular endothelial cell number ( J:150211 )

• endothelial hyperplasia is associated with defects in pericyte recruitment

abnormal pericyte morphology ( J:150211 )

• fewer pericytes are recruited to microvasculature compared to in wild-type mice

hematoma ( J:150211 )

• over large areas of the trunk, neck, and head

hemorrhage ( J:150211 )

• at E13.5, mice exhibit multiple regions of vascular hemorrhage unlike in wild-type mice

• at E14.5, large-scale vascular hemorrhage is observed in all mice

• enlarged blood vessels frequently rupture

abnormal vascular endothelial cell physiology ( J:150211 )

• loss of vascular integrity is due to endothelial rupture

homeostasis/metabolism

edema ( J:150211 )

• generalized at E13.5

skin edema ( J:143564 , J:150211 )

• at E13.5 (J:143564)

• 63% of mice exhibit severe subcutaneous edema in the trunk and neck regions un like in wild-type mice (J:150211)

immune system

abnormal lymphatic vessel morphology ( J:143564 )

• lymphatic vessels are finer, denser, and more branched with more loops and fewer blind-ended sacs compared to in wild-type mice

integument

skin edema ( J:143564 , J:150211 )

• at E13.5 (J:143564)

• 63% of mice exhibit severe subcutaneous edema in the trunk and neck regions un like in wild-type mice (J:150211)