Analysis Tools
nervous system
spina bifida
(
J:150128
)
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• in some mice
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• some mice exhibit diastematomyelia, splitting of the spinal cord, due to bony septa in lumbar L3 and L4 vertebrae unlike in wild-type mice
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• 60% of mice exhibit abnormal brain morphology
• brain gray matter is lost in a gradient in some mice unlike in wild-type mice
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hydrocephaly
(
J:150128
)
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• some mice develop secondary hydrocephalus unlike in wild-type mice
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• partial agenesis in some mice
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• in most mice
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• in most mice
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• in most mice due to increased cellular proliferation
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• some mice exhibit deformations in the hippocampal cortex unlike in wild-type mice
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• in most mice, the posterior cortex is smaller than in wild-type mice due to reduced cellular proliferation
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• disorganized in some mice
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• in pronounced cases, dramatic cerebellar herniation through the foramen magnum is observed with secondary hydrocephalus unlike in wild-type mice
• MRI imaging shows herniation of the cerebellar paraflocculus into the foramen magnum with crowded posterior fosssa in some mice unlike in wild-type mice
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behavior/neurological
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• in severe cases, mice exhibit proturbated backs unlike wild-type mice
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• in severe cases
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embryo
spina bifida
(
J:150128
)
|
• in some mice
|
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• some mice exhibit diastematomyelia, splitting of the spinal cord, due to bony septa in lumbar L3 and L4 vertebrae unlike in wild-type mice
|
skeleton
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• some mice exhibit diastematomyelia, splitting of the spinal cord, due to bony septa in lumbar L3 and L4 vertebrae unlike in wild-type mice
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