Mouse Genome Informatics
hm
    Smad9tm3Jfm/Smad9tm3Jfm
involves: 129S4/SvJaeSor
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
respiratory system
• beginning at 11.5 months of age vessels in the lung show signs of defective vascular remodeling
• in 6 of 15 mice, distal pulmonary arterioles show hyperplasia with vessel occlusion and plexiform lesions
• perivascular inflammatory infiltrates are seen in the lungs

tumorigenesis
• seen in 3 of 19 mice

embryogenesis
N
• despite expression of the endogenous gene during development no gross developmental abnormalities are seen (J:150213)

cardiovascular system
• beginning at 11.5 months of age vessels in the lung show signs of defective vascular remodeling
• in 6 of 15 mice, distal pulmonary arterioles show hyperplasia with vessel occlusion and plexiform lesions

immune system
• perivascular inflammatory infiltrates are seen in the lungs

Mouse Models of Human Disease
OMIM IDRef(s)
Pulmonary Hypertension, Primary, 1; PPH1 178600 J:150213