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Phenotypes Associated with This Genotype
Genotype
MGI:3850122
Allelic
Composition
Smad9tm3Jfm/Smad9tm3Jfm
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad9tm3Jfm mutation (0 available); any Smad9 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• beginning at 11.5 months of age vessels in the lung show signs of defective vascular remodeling
• in 6 of 15 mice, distal pulmonary arterioles show hyperplasia with vessel occlusion and plexiform lesions
• perivascular inflammatory infiltrates are seen in the lungs
• seen in 3 of 19 mice

tumorigenesis
• seen in 3 of 19 mice

embryogenesis
N
• despite expression of the endogenous gene during development no gross developmental abnormalities are seen

cardiovascular system
• beginning at 11.5 months of age vessels in the lung show signs of defective vascular remodeling
• in 6 of 15 mice, distal pulmonary arterioles show hyperplasia with vessel occlusion and plexiform lesions

immune system
• perivascular inflammatory infiltrates are seen in the lungs

Mouse Models of Human Disease
OMIM ID Ref(s)
Pulmonary Hypertension, Primary, 1; PPH1 178600 J:150213


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory