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Phenotypes Associated with This Genotype
Genotype
MGI:3850051
Allelic
Composition		 Nlrp3tm2Hhf/Nlrp3+
Tg(CAG-cre/Esr1*)5Amc/?
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3tm2Hhf mutation (1 available); any Nlrp3 mutation (61 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
slow postnatal weight gain ( J:150054 )
• some older mice have slower weight gain

immune system
skin inflammation ( J:150054 )
• some older mice develop skin inflammation suggesting leaky expression of the cre recombinase

integument
skin inflammation ( J:150054 )
• some older mice develop skin inflammation suggesting leaky expression of the cre recombinase

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory