immune system
• peritoneal macrophages are able to secrete IL-1beta in the absence of ATP when activated in vitro
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• bone marrow derived dendritic cells hypersecrete the mature form of IL-1beta in response to activation
• the maximal response is 300-fold greater than controls
• DCs are able to secrete IL1-beta without the presence of exogenous ATP
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• mutant DCs cells have an enhanced ability to stimulate T cells to differentiate into a Th17 subtypes when presenting cognate antigen
• mutant DCs also enhance Th1 and Th2 differentation when co-cultured with T cells in the presence of polarizing cytokines
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hematopoietic system
• peritoneal macrophages are able to secrete IL-1beta in the absence of ATP when activated in vitro
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