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Phenotypes Associated with This Genotype
Genotype
MGI:3850050
Allelic
Composition
Nlrp3tm1Hhf/Nlrp3+
Tg(CAG-cre/Esr1*)5Amc/?
Genetic
Background
involves: 129/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3tm1Hhf mutation (1 available); any Nlrp3 mutation (28 available)
Tg(CAG-cre/Esr1*)5Amc mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• peritoneal macrophages are able to secrete IL-1beta in the absence of ATP when activated in vitro
• bone marrow derived dendritic cells hypersecrete the mature form of IL-1beta in response to activation
• the maximal response is 300-fold greater than controls
• DCs are able to secrete IL1-beta without the presence of exogenous ATP
• mutant DCs cells have an enhanced ability to stimulate T cells to differentiate into a Th17 subtypes when presenting cognate antigen
• mutant DCs also enhance Th1 and Th2 differentation when co-cultured with T cells in the presence of polarizing cytokines

hematopoietic system
• peritoneal macrophages are able to secrete IL-1beta in the absence of ATP when activated in vitro

Mouse Models of Human Disease
OMIM ID Ref(s)
Muckle-Wells Syndrome; MWS 191900 J:150054


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory