Analysis Tools
growth/size/body
weight loss
(
J:150024
)
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• there is more than a 10% reduction in mean weight of mice compared to controls at 5 months of age
|
digestive/alimentary system
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• modest salivary gland inflammation is observed in mice at 5 months of age
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immune system
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• there are slightly more CD8+ T cells than CD4+ T cells among splenocytes
|
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• there is a higher percentage of T cells expressing activation markers
|
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• thymus weight at 5 months of age is reduced by more than a third
|
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• thymus cellularity is reduced by more than two-thirds at 1 month of age
|
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• spleen weight is reduced by about a third at 2 months of age
|
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• spleen cellularity is about half that of controls at 5 months of age
|
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• interferon-gamma secretion is enhanced in mutant T cells when activated with various stimuli
|
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• interleukin-2 secretion is enhanced in mutant T cells when activated with various stimuli
|
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• modest salivary gland inflammation is observed in mice at 5 months of age
|
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• modest inflammation is observed in the lungs at 5 months of age
|
respiratory system
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• modest inflammation is observed in the lungs at 5 months of age
|
endocrine/exocrine glands
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• modest salivary gland inflammation is observed in mice at 5 months of age
|
|
• thymus weight at 5 months of age is reduced by more than a third
|
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• thymus cellularity is reduced by more than two-thirds at 1 month of age
|
hematopoietic system
|
• thymus weight at 5 months of age is reduced by more than a third
|
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• thymus cellularity is reduced by more than two-thirds at 1 month of age
|
|
• there are slightly more CD8+ T cells than CD4+ T cells among splenocytes
|
|
• spleen weight is reduced by about a third at 2 months of age
|
|
• spleen cellularity is about half that of controls at 5 months of age
|
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• there is a higher percentage of T cells expressing activation markers
|
