Phenotypes Associated with This Genotype

Genotype
MGI:3849560

• Allelic Composition: Vegfa^tm1Dco/Vegfa^tm1Dco
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:32219 )

• no viable mice are obtained at birth

cardiovascular system

abnormal vascular development ( J:32219 )

• at E9.5, vascular structures are enlarged in the anterior part of the embryo

abnormal dorsal aorta morphology ( J:32219 )

• at E8.5, the dorsal aorta is absent in the anterior part of the embryo

abnormal vascular endothelial cell differentiation ( J:32219 )

• endothelial cell development is delayed compared to in wild-type mice

cellular

abnormal vascular endothelial cell differentiation ( J:32219 )

• endothelial cell development is delayed compared to in wild-type mice