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Phenotypes Associated with This Genotype
Genotype
MGI:3849439
Allelic
Composition
Tg(Lck-Tal1)4709Led/0
Genetic
Background
FVB/N-Tg(Lck-Tal1)4709Led
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 350 days

neoplasm
• mice develop clonal T cell lymphoblastic leukemia/lymphoma
• mice exhibit lymphoblastic infiltrates in the thymus, para-sternal muscle, pericardium, spleen, liver, and kidneys
• mice develop clonal T cell lymphoblastic leukemia/lymphoma

immune system
• mice develop thymic masses composed of lymphoblastic cells with prominent nucleoli and scant cytoplasm unlike wild-type mice

respiratory system
• in mice that develop tumors

liver/biliary system

growth/size/body
• in mice that develop tumors

hematopoietic system
• mice develop thymic masses composed of lymphoblastic cells with prominent nucleoli and scant cytoplasm unlike wild-type mice

integument
• in mice that develop tumors

endocrine/exocrine glands
• mice develop thymic masses composed of lymphoblastic cells with prominent nucleoli and scant cytoplasm unlike wild-type mice
• mice develop clonal T cell lymphoblastic leukemia/lymphoma

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
lymphocytic leukemia DOID:1037 J:36076


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory