Phenotypes for En1 Rfng MGI:3849435 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	En1^tm1Alj/En1^tm1Alj Rfng^tm1Tfv/Rfng^tm1Tfv
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm1Alj mutation (2 available); any En1 mutation (34 available)
Rfng^tm1Tfv mutation (0 available); any Rfng mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal limb development ( J:149312 )

• indistinguishable from mice with one wild-type Rfng allele at all stages examined

abnormal apical ectodermal ridge morphology ( J:149312 )

• at E10.5 the AER appears flattened and ventrally expanded

• by E11.5, clefts and bifurcations are seen along with ventral anterior nubs

• 2 distinct ectodermal ridges are present

embryo

abnormal apical ectodermal ridge morphology ( J:149312 )

• at E10.5 the AER appears flattened and ventrally expanded

• by E11.5, clefts and bifurcations are seen along with ventral anterior nubs

• 2 distinct ectodermal ridges are present

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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