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Phenotypes Associated with This Genotype
Genotype
MGI:3849425
Allelic
Composition		 Mecomtm1.1Miku/Mecom+
Genetic
Background		 B6.Cg-Mecomtm1.1Miku
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecomtm1.1Miku mutation (0 available); any Mecom mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal platelet morphology ( J:149794 )
• platelets have delayed recovery of numbers after administration of Fluorouracil
abnormal hematopoietic stem cell morphology ( J:149794 )
• less mutant HSC than wild-type HSC reconstitute the bone marrow of lethally irradiated mice in competitive reconstitution assays
decreased hematopoietic stem cell number ( J:149794 )
• the population of lin- Kit+CD34+ found among E14.5 fetal liver cells 2-3 fold compared to controls
• this population is also reduced by about half in the bone marrow of adult mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory