Phenotypes Associated with This Genotype

Genotype
MGI:3849419

• Allelic Composition: Gars1^C201R/Gars1⁺
• Genetic Background: involves: BALB/cAnN * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:149830 )

• mice exhibit impaired coordination on a rotarod compared with wild-type mice

impaired fine motor coordination ( J:149830 )

• in a mouse reach and grasp assay, mice exhibit reduced motor flexibility and decreased fine motor control compared with wild-type mice

decreased grip strength ( J:149830 )

• Background Sensitivity: male mouse grip strength is reduced 40% compared to that of wild-type mice on mixed BALB/cAnN and C3H/HeH background whereas grip strength is reduced 57% on a mixed BALB/cAnN, C3H/HeH, and C57BL/6 background

decreased locomotor activity ( J:149830 )

nervous system

nervous system phenotype ( J:149830 )

N • at E12.5, the peripheral nervous system appears normal

N • at P15 and 17 months, mice exhibit normal brain and spinal cord morphology

abnormal sciatic nerve morphology ( J:149830 )

• at 17 months, the number of large diameter axons in the sciatic nerve is decreased 50% compared to in wild-type mice