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Phenotypes Associated with This Genotype
Genotype
MGI:3849204
Allelic
Composition		 Arhgef12tm1.1Wet/Arhgef12tm1.1Wet
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef12tm1.1Wet mutation (0 available); any Arhgef12 mutation (88 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell proliferation ( J:149560 )
• CD4+ T cells have less impairment of in vitro proliferation when a RhoA activator is used

immune system
abnormal T cell proliferation ( J:149560 )
• CD4+ T cells have less impairment of in vitro proliferation when a RhoA activator is used

cellular
abnormal T cell proliferation ( J:149560 )
• CD4+ T cells have less impairment of in vitro proliferation when a RhoA activator is used

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory