Phenotypes Associated with This Genotype

Genotype
MGI:3849203

• Allelic Composition: Gna12^tm1Citb/Gna12^tm1Citb; Gna13^tm2.1Soff/Gna13^tm2.1Soff; Tg(Lck-cre)548Jxm/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:149560 )

• homeostatic CD4⁺ T cell proliferation is increased within the lymph nodes

• allogenic stimulation of CD4⁺ T cells is also increased

thymus hyperplasia ( J:149560 )

• thymus weight and cellularity is increased by about a third

increased CD4-positive, alpha-beta T cell number ( J:149560 )

• CD4⁺ T cell numbers in the lymph nodes and blood are increased by about a third

increased CD8-positive, alpha-beta T cell number ( J:149560 )

• CD8⁺ T cell numbers in the lymph nodes are slightly increased

abnormal CD4-positive, alpha-beta T cell physiology ( J:149560 )

• CD4⁺ T cells have longer interactions between themselves and with allogenic dendritic cells

• CD4⁺ T cells have a higher affinity for ICAM-coated surfaces

• CD4⁺ T cells have decreased motility through transwell filters

• CD4⁺ T cells transferred into wild-type mice have enhanced enhanced transendothelial migration into lymph nodes

lymph node hyperplasia ( J:149560 )

• axillary, cervical, inguinal and mesenteric lymph nodes are increased in weight and cell number by about a third

increased susceptibility to type IV hypersensitivity reaction ( J:149560 )

• an increase in ear thickness is observed after sensitization and challenge with DNFB

• CD4⁺ T cells in cervical lymph nodes have a higher proliferation rate than those of control mice after DNFB challenge

increased interleukin-2 secretion ( J:149560 )

• IL-2 secretion is enhanced by CD4⁺ T cells in response to allogenic stimulation

increased susceptibility to autoimmune diabetes ( J:149560 )

• diabetes development is accelerated and aggravated after streptozotocin induction with high glucose levels detected

• peripancreatic lymph nodes are enlarged 5-6 days after disease induction

• increased numbers of CD4⁺ T cells are noted in the pancreas 14 days after disease induction compared to controls

hematopoietic system

increased T cell proliferation ( J:149560 )

• homeostatic CD4⁺ T cell proliferation is increased within the lymph nodes

• allogenic stimulation of CD4⁺ T cells is also increased

thymus hyperplasia ( J:149560 )

• thymus weight and cellularity is increased by about a third

increased CD4-positive, alpha-beta T cell number ( J:149560 )

• CD4⁺ T cell numbers in the lymph nodes and blood are increased by about a third

increased CD8-positive, alpha-beta T cell number ( J:149560 )

• CD8⁺ T cell numbers in the lymph nodes are slightly increased

abnormal CD4-positive, alpha-beta T cell physiology ( J:149560 )

• CD4⁺ T cells have longer interactions between themselves and with allogenic dendritic cells

• CD4⁺ T cells have a higher affinity for ICAM-coated surfaces

• CD4⁺ T cells have decreased motility through transwell filters

• CD4⁺ T cells transferred into wild-type mice have enhanced enhanced transendothelial migration into lymph nodes

endocrine/exocrine glands

thymus hyperplasia ( J:149560 )

• thymus weight and cellularity is increased by about a third

cellular

increased T cell proliferation ( J:149560 )

• homeostatic CD4⁺ T cell proliferation is increased within the lymph nodes

• allogenic stimulation of CD4⁺ T cells is also increased