Phenotypes Associated with This Genotype

Genotype
MGI:3849012

• Allelic Composition: Nfatc2^tm1Srf/Nfatc2^tm1Srf
• Genetic Background: B6.Cg-Nfatc2^tm1Srf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased immunoglobulin level ( J:86279 )

increased IgE level ( J:86279 )

• as a result of infection with either Nippostrongylus brasiliensis or Mycobacterium bovis

increased IgG1 level ( J:86279 )

• as a result of Nippostrongylus brasiliensis infection

abnormal CD4-positive, alpha-beta T cell physiology ( J:86279 )

abnormal T-helper 1 physiology ( J:86279 )

• Th1 responses are decreased overall

abnormal T-helper 2 physiology ( J:86279 )

• Th2 responses are increased overall

decreased interferon-gamma secretion ( J:86279 )

• Mycobacterium bovis infection results in lowered Ifn gamma secretion

increased interleukin-4 secretion ( J:86279 )

• Nippostrongylus brasiliensis infection leads to significantly increased Il4 and Il5 secretion

increased interleukin-5 secretion ( J:86279 )

• Nippostrongylus brasiliensis infection leads to significantly increased Il4 and Il5 secretion

hematopoietic system

increased immunoglobulin level ( J:86279 )

increased IgE level ( J:86279 )

• as a result of infection with either Nippostrongylus brasiliensis or Mycobacterium bovis

increased IgG1 level ( J:86279 )

• as a result of Nippostrongylus brasiliensis infection

abnormal CD4-positive, alpha-beta T cell physiology ( J:86279 )

abnormal T-helper 1 physiology ( J:86279 )

• Th1 responses are decreased overall

abnormal T-helper 2 physiology ( J:86279 )

• Th2 responses are increased overall