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Phenotypes Associated with This Genotype
Genotype
MGI:3849012
Allelic
Composition
Nfatc2tm1Srf/Nfatc2tm1Srf
Genetic
Background
B6.Cg-Nfatc2tm1Srf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc2tm1Srf mutation (0 available); any Nfatc2 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• as a result of infection with either Nippostrongylus brasiliensis or Mycobacterium bovis
• as a result of Nippostrongylus brasiliensis infection
• Th1 responses are decreased overall
• Th2 responses are increased overall
• Mycobacterium bovis infection results in lowered Ifn gamma secretion
• Nippostrongylus brasiliensis infection leads to significantly increased Il4 and Il5 secretion
• Nippostrongylus brasiliensis infection leads to significantly increased Il4 and Il5 secretion

hematopoietic system
• as a result of infection with either Nippostrongylus brasiliensis or Mycobacterium bovis
• as a result of Nippostrongylus brasiliensis infection
• Th1 responses are decreased overall
• Th2 responses are increased overall


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory