Phenotypes for Dll1 MGI:3848986 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dll1^tm1Gos/Dll1^tm2Gos
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1^tm1Gos mutation (2 available); any Dll1 mutation (45 available)
Dll1^tm2Gos mutation (0 available); any Dll1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:148902 )

cardiovascular system

artery stenosis ( J:148902 )

• lumens of large arteries show a reduction in diameters at E18.5, with no significant differences in arterial wall thickness

aorta stenosis ( J:148902 )

• lumen shows a reduction in diameter compared to controls

abnormal capillary branching pattern ( J:148902 )

• significant increase in capillary branch points in the skin is observed at E17.5

abnormal skin vasculature morphology ( J:148902 )

• significant increase in capillary branch points in the skin is observed at E17.5

muscle

abnormal muscle morphology ( J:148902 )

abnormal myogenesis ( J:148902 )

decreased skeletal muscle mass ( J:148902 )

integument

abnormal skin vasculature morphology ( J:148902 )

• significant increase in capillary branch points in the skin is observed at E17.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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