Phenotypes Associated with This Genotype

Genotype
MGI:3848927

• Allelic Composition: Ncstn^tm1.1Sud/Ncstn^tm1.1Sud; Tg(Camk2a-cre)1Shn/0
• Genetic Background: B6.Cg-Ncstn^tm1.1Sud Tg(Camk2a-cre)1Shn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:149506 )

N • brain morphology is normal at 2 months

gliosis ( J:149506 )

• progressive as early as 2 months

astrocytosis ( J:149506 )

increased neuron apoptosis ( J:149506 )

• progressive as early as 2 months

loss of cortex neurons ( J:149506 )

• at 6 and 9 months, mice exhibit cortical atrophy with loss of cortical neurons unlike wild-type mice

thin cerebral cortex ( J:149506 )

• at 6 and 9 months, neocortical volume is decreased compared to in wild-type mice

decreased CNS synapse formation ( J:149506 )

• age-dependent

abnormal dendrite morphology ( J:149506 )

• mice exhibit age-dependent dendrite loss unlike wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:149506 )

N • mice exhibit normal swimming abilities, activity levels, and coordination

impaired contextual conditioning behavior ( J:149506 )

• long term-term associative fear memory in a contextual conditioning assay is impaired in an age-dependent manner compared to in wild-type mice

abnormal spatial learning ( J:149506 )

• in a Morris water maze, mice exhibit age-dependent impaired spatial learning compared with wild-type mice

impaired spatial working memory ( J:149506 )

• in a Morris water maze with hidden platform, mice exhibit age-dependent impaired spatial memory compared with wild-type mice

cellular

gliosis ( J:149506 )

• progressive as early as 2 months

astrocytosis ( J:149506 )

increased neuron apoptosis ( J:149506 )

• progressive as early as 2 months