Phenotypes Associated with This Genotype

Genotype
MGI:3848827

• Allelic Composition: Rasgrf1^tm1Toc/Rasgrf1⁺
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:47681 )

• when the mutant allele is paternally inherited

• weight at 3-4 weeks of age is reduced 25% in females and 30% in males

• adults are persistently 15-25% smaller

postnatal growth retardation ( J:47681 )

• postnatal growth is slower when the mutant allele is paternally inherited

endocrine/exocrine glands

abnormal pituitary secretion ( J:47681 )

• pituitary growth hormone levels are reduced 42-53% when the mutant allele is paternally inherited

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:47681 )

• reduced 32-40% at 4 weeks of age when the mutant allele is paternally inherited

decreased growth hormone level ( J:47681 )

• contained 42-53% less growth hormone than the wild-type controls when the mutant allele is paternally inherited

cellular

maternal imprinting ( J:47681 )

nervous system

abnormal pituitary secretion ( J:47681 )

• pituitary growth hormone levels are reduced 42-53% when the mutant allele is paternally inherited