About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3848801
Allelic
Composition		 Zfxtm1.1Reiz/Y
Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129/Sv * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Thl mutation (0 available); any Gt(ROSA)26Sor mutation (1062 available)
Zfxtm1.1Reiz mutation (0 available); any Zfx mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal common lymphocyte progenitor cell morphology ( J:149654 )
• as early as 4 days after tamoxifen-induction
decreased hematopoietic stem cell number ( J:149654 )
• following tamoxifen treatment, the number of hematopoietic stem cell-containing LSK populations is decreased compared to in similarly treated wild-type mice
abnormal hematopoietic system physiology ( J:149654 )
• following tamoxifen treatment, maintenance of adult hematopoietic cells is abolished compared to in similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory