Phenotypes Associated with This Genotype

Genotype
MGI:3848800

• Allelic Composition: Slc30a3^tm1Rpa/Slc30a3⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased brain zinc level ( J:53059 )

• heterozygotes display a ~10% reduction in total zinc levels in the hippocampus and cortex relative to wild-type mice

• Timm stain is reduced in the hippocampus, neocortex, piriform cortex, amygdala, entorhinal cortex, striatum, olfactory bulb, and cochlear nucleus of heterozygous mutant mice

• in the hippocampus, Timm staining is reduced in the mossy fibers projecting from dentate granule neurons to the hilus and s lucidum and s oriens of the CA3 region, and in projections to s radiatum and s oriens of the CA1 region

• Timm-staining is reduced within the synaptic vesicles of heterozygous mutant mossy fiber boutons

• TSQ fluorescenceis reduced by 47% in the hilus, 39% in the CA3 region, and 50% in the CA1 region of heterozygous mutant hippocampi