Phenotypes Associated with This Genotype

Genotype
MGI:3848515

• Allelic Composition: Nkx3-2^tm1(cre)Wez/Nkx3-2^tm1(cre)Wez
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

absent basioccipital bone ( J:148724 )

• loss of this bone of the cranial vault is observed at E18.5

absent basisphenoid bone ( J:148724 )

• observed at E18.5

skeleton

abnormal skeleton morphology ( J:148724 )

• skeletons are defective; skeletal anomalies are similar to those reported for other Nkx3-2 null homozygotes

absent basioccipital bone ( J:148724 )

• loss of this bone of the cranial vault is observed at E18.5

absent basisphenoid bone ( J:148724 )

• observed at E18.5

abnormal vertebral column morphology ( J:148724 )

• absence of midline structures in vertebral column is observed in E18.5 embryos

growth/size/body

absent basisphenoid bone ( J:148724 )

• observed at E18.5