Phenotypes Associated with This Genotype

Genotype
MGI:3848446

• Allelic Composition: Chl1^tm1Msch/Chl1^tm1Msch; Tg(Camk2a-cre)1Gsc/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:143051 )

N • mice exhibit normal learning performance in Lashley Maze, passive avoidance, odor discrimination, spatial water maze, and fear conditioning

N • mice exhibit normal sensory and motor ability

abnormal learning/memory/conditioning ( J:143051 )

• mice exhibit an impairment in working memory duration compared with wild-type mice

• however, selective attention is normal

abnormal spatial working memory ( J:143051 )

• performance in a radial arm maze is worse than for wild-type mice

abnormal response to novel object ( J:143051 )

• mice do not spend increased time exploring a novel object unlike wild-type mice