About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3848443
Allelic
Composition
Nxf2tm1.2Jw/Y
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nxf2tm1.2Jw mutation (0 available); any Nxf2 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• female mice exhibit normal fertility
• at Stage XII of spermatogenesis in one third of mice
• in 29% of mice
• anaphase cells exhibit chromosome segregation is chaotic unlike in wild-type mice
• Background Sensitivity: on a mixed 129/Sv and C57BL/6 background, progression of meiosis is impaired unlike on a congenic C57BL/6J background
• however, the number of chromosome crossover sites is normal
• in males with small testes
• one third of male mice are infertile unlike wild-type mice
• however, remaining mice exhibit normal fertility

endocrine/exocrine glands
• in 29% of mice

cellular
• at Stage XII of spermatogenesis in one third of mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/23/2024
MGI 6.23
The Jackson Laboratory