Phenotypes Associated with This Genotype

Genotype
MGI:3848360

• Allelic Composition: Irak2^tm1Jth/Irak2^tm1Jth
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:149258 )

• only 10% of LPS-treated mice die compared with 80% of similarly treated wild-type mice

immune system

decreased circulating interleukin-6 level ( J:149258 )

• LPS-treated mice exhibit lower serum IL6 concentration compared with similarly treated wild-type mice

decreased circulating tumor necrosis factor level ( J:149258 )

• LPS-treated mice exhibit lower serum TNF-alpha concentration compared with similarly treated wild-type mice

abnormal chemokine level ( J:149258 )

• LPS-treated mice exhibit lower serum CXCL1 (KC) concentration compared with similarly treated wild-type mice

• LPS- or R848-treated macrophages produce less chemokine (CXCL1) compared with similarly treated wild-type cells

decreased interleukin-6 secretion ( J:149258 )

• LPS- or R848-treated macrophages produce less cytokines IL6 compared with similarly treated wild-type cells

decreased tumor necrosis factor secretion ( J:149258 )

• LPS- or R848-treated macrophages produce less TNF-alpha compared with similarly treated wild-type cells

decreased susceptibility to endotoxin shock ( J:149258 )

• only 10% of LPS-treated mice die compared with 80% of similarly treated wild-type mice

• LPS-treated mice exhibit lower serum cytokine (IL6 and TNF-alpha) and chemokine concentrations compared with similarly treated wild-type mice

• LPS- or R848-treated macrophages produce less cytokines (IL6 and TNF-alpha) and chemokine (CXCL1) compared with similarly treated wild-type cells

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:149258 )

• LPS-treated mice exhibit lower serum IL6 concentration compared with similarly treated wild-type mice

decreased circulating tumor necrosis factor level ( J:149258 )

• LPS-treated mice exhibit lower serum TNF-alpha concentration compared with similarly treated wild-type mice

abnormal chemokine level ( J:149258 )

• LPS-treated mice exhibit lower serum CXCL1 (KC) concentration compared with similarly treated wild-type mice

• LPS- or R848-treated macrophages produce less chemokine (CXCL1) compared with similarly treated wild-type cells