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Phenotypes Associated with This Genotype
Genotype
MGI:3848337
Allelic
Composition		 Lrrc4tm1Lex/Lrrc4tm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrc4tm1Lex mutation (3 available); any Lrrc4 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:149048 )
N
• inner ear morphology appears normal
abnormal auditory brainstem response waveform shape ( J:149048 )
• the amplitude of ABR waves is decreased at every decibel level compared to in wild-type mice
• however, ABR latency and threshold are normal

behavior/neurological
absent startle reflex ( J:149048 )
• 7 of 8 mice exhibit no startle response
hyperactivity ( J:149048 )
• in an open field test

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory