Phenotypes Associated with This Genotype

Genotype
MGI:3848171

• Allelic Composition: Jag1^tm1Grid/Jag1^tm1.1Loo; Tg(Alb1-cre)1Khk/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

bile duct proliferation ( J:149131 )

• diffuse bile duct proliferation is observed around small and large bile ducts by 4 weeks of age

• by 12 weeks of age, 50% of mice have bile duct proliferation with these ducts appearring small and slit-like

dilated bile duct ( J:149131 )

• at 8 weeks of age, some mice have dilated bile tracts and expanded portal tracts

• cytokeratin staining also shows irregular, dilated ducts surrounding the periphery of many portal tracts

abnormal bile secretion ( J:149131 )

• bile stasis is identified within the lumina of several proliferating ducts

endocrine/exocrine glands

bile duct proliferation ( J:149131 )

• diffuse bile duct proliferation is observed around small and large bile ducts by 4 weeks of age

• by 12 weeks of age, 50% of mice have bile duct proliferation with these ducts appearring small and slit-like

dilated bile duct ( J:149131 )

• at 8 weeks of age, some mice have dilated bile tracts and expanded portal tracts

• cytokeratin staining also shows irregular, dilated ducts surrounding the periphery of many portal tracts