Phenotypes Associated with This Genotype

Genotype
MGI:3847929

• Allelic Composition: Elavl1^tm1Dkon/Elavl1^tm1Dkon; Tg(Lck-cre)I57Jxm/0
• Genetic Background: B6.Cg-Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal positive T cell selection ( J:148866 )

• there is a relative decrease in the DP thymocytes initiating (TCRbeta^intCD69^high) and undergoing (TCRbeta^highCD69^high)positive selection

increased double-negative T cell number ( J:148866 )

• double negative thymocyte numbers are significantly increased in number starting at 4 weeks of age

• the largest increase in numbers occur in the DN4 population

increased double-positive T cell number ( J:148866 )

• double positive thymocyte numbers are significantly increased in number starting at 10 weeks of age

decreased CD4-positive, alpha-beta T cell number ( J:148866 )

• splenic CD4⁺ T cell numbers are significantly less than controls

• with age, numbers drop below half that in controls

decreased CD8-positive, alpha-beta T cell number ( J:148866 )

• splenic CD8⁺ T cell numbers are significantly less than controls

• with age, numbers drop below half that in controls

increased single-positive T cell number ( J:148866 )

• double positive thymocyte numbers are significantly increased in number starting at 10 weeks of age

abnormal T cell physiology ( J:148866 )

• the ability of thymocytes to egress from the thymus is reduced in these mice

• the number of recent thymic emigrants in the periphery is reduced by about a third

• thymocytes migrate poorly to CXCL12 or CCR7

abnormal thymocyte activation ( J:148866 )

• about twice as many thymocytes in both the double negative and double positive subsets are in the S or G2/M phase

• thymocytes have a reduced response to TCR stimulation

hematopoietic system

abnormal positive T cell selection ( J:148866 )

• there is a relative decrease in the DP thymocytes initiating (TCRbeta^intCD69^high) and undergoing (TCRbeta^highCD69^high)positive selection

increased double-negative T cell number ( J:148866 )

• double negative thymocyte numbers are significantly increased in number starting at 4 weeks of age

• the largest increase in numbers occur in the DN4 population

increased double-positive T cell number ( J:148866 )

• double positive thymocyte numbers are significantly increased in number starting at 10 weeks of age

decreased CD4-positive, alpha-beta T cell number ( J:148866 )

• splenic CD4⁺ T cell numbers are significantly less than controls

• with age, numbers drop below half that in controls

decreased CD8-positive, alpha-beta T cell number ( J:148866 )

• splenic CD8⁺ T cell numbers are significantly less than controls

• with age, numbers drop below half that in controls

increased single-positive T cell number ( J:148866 )

• double positive thymocyte numbers are significantly increased in number starting at 10 weeks of age

abnormal T cell physiology ( J:148866 )

• the ability of thymocytes to egress from the thymus is reduced in these mice

• the number of recent thymic emigrants in the periphery is reduced by about a third

• thymocytes migrate poorly to CXCL12 or CCR7

abnormal thymocyte activation ( J:148866 )

• about twice as many thymocytes in both the double negative and double positive subsets are in the S or G2/M phase

• thymocytes have a reduced response to TCR stimulation

endocrine/exocrine glands

abnormal thymocyte activation ( J:148866 )

• about twice as many thymocytes in both the double negative and double positive subsets are in the S or G2/M phase

• thymocytes have a reduced response to TCR stimulation