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Phenotypes Associated with This Genotype
Genotype
MGI:3847566
Allelic
Composition		 Smn1tm1Msd/Smn1tm1Msd
Tg(SMN1*A2G)2023Ahmb/0
Tg(SMN2*A111G)588Ahmb/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm1Msd mutation (37 available); any Smn1 mutation (87 available)
Tg(SMN1*A2G)2023Ahmb mutation (3 available)
Tg(SMN2*A111G)588Ahmb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:148541 )
• no animals of this genotype are observed at birth, indicating that the two missense SMN alleles cannot complement one another to form a functional complex and rescue the Smn1 deficiency

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory