Phenotypes Associated with This Genotype

Genotype
MGI:3846793

• Allelic Composition: Smurf1^tm1Wran/Smurf1^tm1Wran; Smurf2^tm1Wran/Smurf2^tm1Wran
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:148693 )

• most mice die around E10.5 and all mice are dead by E12.5

nervous system

abnormal embryonic neuroepithelium morphology ( J:148693 )

• at E8.75, mice exhibit neuroectoderm that is splayed open with ectopic invaginations and an expanded floor plate unlike in wild-type mice

• however, dorso-lateral hinge points form

enlarged floor plate ( J:148693 )

• expanded at E8.75

open neural tube ( J:148693 )

• 65% of mice display open neural tubes at 6 somite stage unlike wild-type mice

embryo

abnormal gastrulation ( J:148693 )

• 35% of mice display gastrulation defects characterized by abnormal posterior structures

abnormal gastrulation movements ( J:148693 )

• the anterior posterior axis is shortened and increased in width compared to in wild-type mice indicative of defective convergent extension movements

abnormal embryonic neuroepithelium morphology ( J:148693 )

• at E8.75, mice exhibit neuroectoderm that is splayed open with ectopic invaginations and an expanded floor plate unlike in wild-type mice

• however, dorso-lateral hinge points form

enlarged floor plate ( J:148693 )

• expanded at E8.75

open neural tube ( J:148693 )

• 65% of mice display open neural tubes at 6 somite stage unlike wild-type mice