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Phenotypes Associated with This Genotype
Genotype
MGI:3846742
Allelic
Composition		 Hprt1tm1(CAG-Tgfbr1*)Lba/Hprt1tm1(CAG-Tgfbr1*)Lba
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(CAG-Tgfbr1*)Lba mutation (0 available); any Hprt1 mutation (1280 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell activation ( J:148747 )
• T cell receptor activation is highly repressed
• steady-state activation of T cells is normal

immune system
abnormal T cell activation ( J:148747 )
• T cell receptor activation is highly repressed
• steady-state activation of T cells is normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory