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Phenotypes Associated with This Genotype
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Slc6a3-PARK2*Q311X)AXwy mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• in beam tests, mice show more errors per step while traversing the beam compared with age; significant age effect is observed with performance in 3-6 month-old animals being comparable to controls but markedly impaired at 16-19 months
• at 16-19 months, mice make significantly fewer hindlimb steps compared to controls
• in cylinder tests, mice show decreased rearing compared to controls at 16-19 months
• at 3, 12, 16, and 21 months of age, mice display significantly progressive hypoactivity in open field tests
• in adhesive removal tests, at 16-19 months, mutants show significant deficits at 16-19 months

nervous system
• in the middle and caudal regions of the substantia nigra, significant numbers of alpha synuclein positive neurons are detected at 16 months, but not at 3 months; a chronic accumulation of proteinase K-resistant alpha-synuclein in midbrain neurons is observed in mutants
• dopaminergic neurons in the substantia nigra display oxidative protein damage at 16 months which is not as prevalent in wild-type mice
• at 16 months, mice have a 40% reduction in tyrosine hydroxylase-positive neurons in the substantia nigra pars compacta (SNc) coincident with a 30% reduction in total neuron number indicating a late-onset dopaminergic neuron loss

• in adhesive removal tests, at 16-19 months, mutants show significant deficits at 16-19 months

• in 19-21 month-old animals, dopamine (DA) levels are significantly reduced compared to controls which correlates with multiple hypokinetic motor deficits like open-field motor activity and vertical plane entries

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease 2 DOID:0060368 OMIM:600116

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory